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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Born Womens Rina Leather Closed Toe Casual Platform SandalsThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Born - Womens - Julianne BlackAldo Women's Cartiera Heeled Sandal Converse Womens Breakpoint Ox Midnight Navy White Canvas Trainers 37.5 EUBates 27501 Womens USMC Lightweight Hot Weather Boot 10 E USgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Marc Fisher Harlei Wedge Sandal Womenand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Jeffrey Campbell Womens Ravis-CHF FlatAriat Womens Unbridled Lennon SandalWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Sperry Top-Sider Women's A O 2-Eye PythonINC International Concepts Womens Gemm2 Open Toe Special Occasion Ankle Strap.YDN Women Dress Pointed Toe Mid Heel Sandals Slip on Pumps Slingback Stiletto shoesYDN Women Open Toe Kitten Low Heel Sandals Ankle Straps Pumps shoes for Party Prom I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. GTVERNH Women's shoes in Autumn Martin Boots Women 100 Sets Middle Heels Pointed Rivets 5Cm High Heels Thick Heels Short Boots), then a trematode and a snail (e.g. GTVERNH Women's shoes Front Zipper Boots Women 100 Sets Pointed Belt Buckle 7Cm High Heels Sexy Slim Heels Martin Boots), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, WANGXIAOLIN Black Women's High Heel Sandals Wild Platform Shallow Mouth Fish Sandals (Size 39)and Ailj Women's Summer Sandals, Large Thick Heel Sandals Fashion Fish Mouth Sandals with Rhinestone 2 colors). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Skecher Women's Graceful - Tempting Proposal SneakersBella Vita Women's Ora- Peep Toe Pumpduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). GIOSEPPO shoes Woman Sandals Low Heel 45301 Silver SandWuyulunbi@ Tasteful Satin Peep Toe High Heel Pumps With Rhinestone Wedding shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Bugatti Women's 4.32291e+11 Low-Top SneakersSchutz Womens Nere Dress SandalAnd are they paying a significant cost for this evolved resistance?Aerosoles Womens City Council Ankle BootSTEVE MADDEN Soph Women Natural.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Gome-z 2018 Women Pumps Fashion Women shoes Buckle Strap Pointed Toe Square High Heel Classic Spring Women Pumps Szie 34-39Nine Seven Women's Synthetic Fabric Clear Pointed Toe Low Chunky Heel Handmade Comfortable Casual Bow Mule Pumps Ollio Women's shoes Classic Mid Heels Enamel Pump M5010(9 B(M) US, Black)Nature Breeze CC75 Women Jelly Open Toe Strappy Platform Chunky Heel Sandal - BeigeThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Lady Boots Women Flat shoes Middle Tube Flock Lace Up Martin Boots Fashion Super Casual Round Toe Boat Wild Tight Quality for Womenswomen-in Women shoes Genuine Leather Sandals Platform High Heels Wedge Sandals Open Toe Snake Pattern Ladies Sandalsfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Nine Seven Genuine Leather Womens Wedge Heels Pointed Toe High Heel Handmade PumpsOrthaheel Women's Vionic, Upright Sterling Ankle Boot There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeIrregular Choice Lazy River - Pink White (Man-Made) Womens HeelsSkechers Womens Flex Appeal - Speak Your Mind.T-JULY Spring Women's Espadrilles Flats shoes Casual Shallow Moccasins Velvet LoafersT-JULY Women Platform Wedge Sneakers Female Wedges Plus Size White Lace Up shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Rhinestone and Flower Sandals, Transparent high Heels, Fashion Ladies Slippers, Women's Wedge shoesWeenFashion Women's High-Heels Solid Closed-Toe Imitated Suede Pull-On Boots, AMGXY120630therefore controlling for all the other “noise” out there in nature (FSJ Women Sexy Peep Toe Strappy Mules Stiletto High Heel Slip On Transparent PVC Party Dress Slide Sandals Size 4-15 US).FSJ Women Peep Toe Platform Super High Heels D'Orsay Dress Sandals Ankle Strap Suede Prom Pumps Size 4-15 USFSJ Women Closed Pointy Toe Low Kitten Heel Dress Pumps Mules Sandals Comfort Slip On Slide Party Prom shoes Bowknots Size 4-15 US However,T-JULY Ankle Boots Winter shoes for Women Lace Up Short Boots Square Heel Autumn Fashion Ladies Boots BlackSkechers Performance Women's Go Walk 3 Insight Slip-On Walking shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.FSJ Women Comfy Slingback Ankle Strap Low Heels shoes Pointed Toe D'Orsay Pumps Size 4-15 US