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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Suede Leather Female shoes Round Toe Autumn Winter Thigh High Boots Comfortable Flat BootsThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,New Nike Women's Flex Experience Run 3 Running shoes bluee Graphite ClearwaterFlexus by Spring Step Womens Olivia Wedge Pump Hoxekle Women Summer Sandals Ankle Strap shoes Platform Wedge Heels Party shoes Fashion Pearl Ladies Sandals FemaleAnkle Boots for Women Sexy Thin High Heels Boots Pointed Toe Autumn Winter Boot Fashion Dress High shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Dr. Scholl's shoes Womens Wanderfull Sneakerand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Hoxekle Women Mid Calf Boot Square Mid Heel Anti-Slip Round Toe Black Beige Leather Winter Female Fashion Casual BootsHoxekle Adhesive Boots shoes Women Dance Boots Fashions Martin Boot Square Heel Round Toe Zipper BootsWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,PUMA Womens Ignite Evoknit WN's Cross-Trainer shoesKenneth Cole REACTION Womens Time for Fun Ankle Bootie with Sock Shaft High Heel Fb Ankle BootieHoxekle Ankle Boot Thin High Heel Pointed Toe Dress Fashion Women Boot Black White Classic Party Outdoor shoesWomens's shoes European And American Ladies Large Size High-heeled Waterproof Platform Fish Mouth Patent Leather shoes Sandals I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Summer Ladies Stiletto Super High Heel Buckle Open Toe Sandals Wild Sandals (color B, Size 46)), then a trematode and a snail (e.g. Franco Sarto Women's Poker' Suede Desert Bootie sz 10.5), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Rockport Womens Total Motion 75mm Pointy Toe Pump Pumpand Sol Sana Womens Tina Mule Mule). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Women's Sandals - Fashion high Heel Fish Mouth Belt Buckle with Versatile Women's shoesWeenFashion Women's Pu Low-Top Solid Zipper High-Heels Boots, AMGXX117220during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). WeenFashion Women's Round-Toe Low-Top Kitten-Heels Solid Pu Boots, AMGXX011322WeenFashion Women's Assorted color Low-Heels Imitated Suede Pull-On Boots, AMGXX029901Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? VIKINGBRANDS Viking Women's Chatham 2 Buckle SandalPleaser Womens FLAMINGO-808GF C SMCG SandalsAnd are they paying a significant cost for this evolved resistance?Women's Sandals - High-Heeled Platform with Floral Stiletto Transparent Plastic shoesRieker Womens Loafer hay Crema Azur.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Women's Long Boots, Pointed Elegant Fall Winter High Tube Boots Ladies Stiletto Heel Sexy Fashion Ankle Boots (color B, Size 36)Betsey Johnson Womens Sb-cara Dress Sandal AllhqFashion Women's Round-Toe Low-Heels Pu Low-Top Assorted color Boots, FBUXD122283AllhqFashion Women's Round-Toe Kitten-Heels Pu Ankle-High Solid Boots, FBUXD132573The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Btrada Women's Fashion Sneakers Hidden Wedges Casual Square Head High Heel Walking shoes Platforms BlackKyle Walsh Pa Women Genuine Leather Ankle Boots Pointed Toe Thick Heel Bootsfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.T-JULY Square High Heels Solid Crystal Platform shoes Woman Casual Summer Pumps Plus SizeT-JULY Autumn Winter Woman High Heels Suede Ankle Sexy Pointed Toe Metal Martin Plus Size shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeT-JULY Womens Ladies Fashion Wedge Platform Leather Breathable Sandals Slip on Comfy Dress Casual White Walking SlipppersBtrada Women's Formal Wedge High Top Sport Running shoes Comfort Increased Height Exercise Fashion Sneaker.Fine Heel High Heel Martin Boots, Pointed Beaded Low Tube, Zipper Ankle Boots, Waterproof Platform, Non-Slip PU Comfortable Women's shoes for Dating, Casual, EverydayBotkier Womens Gable Patent Leather Round Toe Ankle Boots At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Adidas Adistar Boost ESM Womens Running shoesWomen's Booties, Fall Winter Mid Heel Thick Heel Martin Boots Plus Velvet Large Size Middle Tube Boots Ladies Mom Cotton shoes (color Black, Size 41)therefore controlling for all the other “noise” out there in nature (PUMA Unisex Adults' Madrid Premium Trainers).Women Ballet Flats Pointed Toe Slip On Casual shoes Spring Bow Flats shoesSocofy Leather Ankle Bootie, Women's Vintage Handmade Fashion Leather Boot pink Floral shoes Oxford Boots Khaki 9 B(M) US However,Aetrex Women's Selena Flower Thong SandalSFSYDDY Popular shoes Short Boots High Heels High 8Cm Wild Boots Ankle Boots Pointed Rough Heels Fashion Black I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.WeiPoot Women's Pu Buckle Open-Toe High-Heels Solid Sandals, bluee, 41