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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Crystal Steve Madden Womens Smile LoaferThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,White 2 iBesun Women's Sneaker Fashion Canvas High-Heeled shoes Pump Lace UP Wedges Side Zipper shoesBlack-Grey-Scarlet Adidas Men's Pureboost RBL Brown Thigh High Boot Knight Boot Women Fashion Round Toe 4Cm Chunkly Heel Knitting color Stovepipe Stretch Boots Dress Boot EU Size 34-40Black Knee High Boots Peep Toe Slingbacks Cool Boot Women Sexy Hollow Cross Straps Party shoes Knight Boots EU Size 34-40generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Grey Suede STEVEN by Steve Madden Womens Lauryn Muleand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Black Combo Capelli New York Solid Ladies Short Basic Body Jelly Rain Boot- Huntty Fur Slippers Open Toe Real Fox Beach Slides 2019 Plus Size Mixed colors Women's Furry Flip Flops Hair shoes,Mixed colors,6We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Yellow Pu Cambridge Select Women's Retro 70s Clog Chunky Platform Block Heel SandalNavy Kidsuede Leather Bella Vita Women's Finn Cutout Sandal with Back Zipper Heeledbluee T-JULY New Luxury Brand Loafers shoes Women Genuine Leather Flat shoes Square Heels LoafersBrown Clarks Unstructured Men's Un.Bend Casual Oxford I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Navy Merrell Womens Applaud Mesh Slide Hiking shoes), then a trematode and a snail (e.g. Black Nbpu Cambridge Select Women's Open Toe Strappy Crystal Rhinestone Stiletto Heel Dress Sandal), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, White Pu Cambridge Select Women's Classic Comfort Chunky Platform Mid Wedge Sandaland Cognac Gentle Souls Womens Eugene Loafer Flat Loafer Flat). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Black Dulce Diva Suede Leather Pointed Toe Chunky Heel Slip On Handmade Over-The-Knee Boots for Women SexyBlack Women Fashion Belt Buckle High Heel Ankle Boots Autumn Winter New Metal Buckle Round Head Martin Boots Side Zipper Party Bootsduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Black T-JULY Wedges Sneakers Women Genuine Leather Platform shoes for Women Autumn Lace-up Casual shoes Height IncreaseGrey-lala-01 SOLE COLLECTION Pointed Toe Ankle Boots Size Zipper Stiletto High Heels Party Wedding Pumps Dress shoes for WomenLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Grey XIANV Women Snow Boots Anti-Slip Soles Waterproof Non-Slip Warm Padded shoes- CALPIERRE Boots Womens Leather BrownAnd are they paying a significant cost for this evolved resistance?Brandon Navy DUNION Women's Brandon Chain Decorated Penny Loafers Low Heels Almond Toe Casual Daily shoesBlack Leather White Cole Haan Men's Original Grand Shortwing Oxfords.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Sand Black Desert 200 Nike Lady Shifter Congreenible Running JacketClay-suede Clarks Originals Men's Desert Boot - CALPIERRE Pumps-shoes Womens Brownbluee hole Cowboy Stretch high Boots high Heel Over The Knee Thick Pointed Martin Boots Female Autumn WinterThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: B Women's Leather shoes Spring & Fall Fashion Ankle Heel shoes Dress shoes Zipper Martin Boots Elastic Socks shoes Walking shoes (color A, Size 37)Red vimedea Womens Heeled 8.7IN Nightclub Party Cross Dressing Oversize US9-19 Platform Pumpfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Mustard Clarks Originals Men's Desert BootWine Red AnMengXinLing Ankle High Boots Women Genuine Leather Pointed Toe High Heel Studded Booties Lace Up Dress Pumps shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placebluee Tint Ecru Tint Active Purple adidas Originals Deerupt Runner shoes Women's CasualWhite Bamboo Charade 24 M Womens Fabric Lace Wedge Platform Sandals.Blk Vegan Leather-clear Pvc Demonia Womens LILITH-271 BVL-PVC BootsBlack Light Green UB-ONEMIX Unisex Air Cushion Outdoor Sport Music Ritmo Deportivas Running shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Trace Olive Black Lime Adidas ORIGINALS Men's NMD_R1 STLTGrey Sofree Women's Knee High Riding Bootstherefore controlling for all the other “noise” out there in nature (Ebony bluee orange Brooks Men's Ravenna 9 Running shoes).Dark Brown Extended Calf Frye Women's Melissa Button BootHhaki MAYPIE Womens Toaffor Leather Zipper Over-The-Knee Boots However,Metal Leather Mirror Leather Sterling Leather Naot Women's Rongo Mary Jane FlatGrey Off White Trace Purple adidas Women's UltraBOOST Running shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Navy DUNION Women's BRINE Comfortable Slip on Chain Decorated Penny Loafers Low Heels Almond Toe Casual Daily shoes