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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Easy Go Shopping Oxford shoes For Men Brogue shoes Lace Up PU Leather Classic Engraved Outsole Patent Leather Cricket shoes (color White, Size 8 UK)The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Men's Moccasins shoes, Men's Loafers Loafers Casual Flat Heel with Genuine Leather Magic Paste Octopus Nonslip Sole Boot Moccasins (color Brown, Size 47 EU) ( color Black , Size 46 EU )Flip-Flops Outdoor Sports Sandalsmen'S Sandals Summer Beach shoes Teen Slippers shoes Men's Driving Penny Loafers Breathable Hollow Upper Genuine Leather Boat Moccasins Soft Sole Dress shoes LeatherZHRUI Mens Breathable Casual shoes Jeans Canvas Slip On Flat Loafers (color bluee, Size 11=46 EU)generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Men's Hiking shoes, Waterproof Walking shoes Low Help Breathable Non Slip for Outdoor Sports Trekking Travelling Climbing,Black,44and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. DALL Sports & Outdoor Sandals Ly-865 Open-toed Men's shoes Black Flat Sandals Slippers Beach shoes Summer Season Outdoor Leisure (Size EU 39 UK 6 CN 39)PUMA Trinomic Blaze Knit Adult's Trainers (359996)We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Men Women Hiking shoes, Winter Fully Fur Lined Mountain Boots Anti-slip Waterproof Safety Boots High Top Wear Resistant Outdoor Walking shoesGBX Hurst Men's Classic Plain Toe Casual Lace up Oxford shoesGLSHI Men's shoes PU Spring Fall Formal shoes Comfort Oxfords for Casual Office & Career Party & Evening White BlackAdidas Men's Cf Racer Tr Fitness shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Yydt Men's shoes Outdoor Sports Outdoor Sandals, Hole shoes, Men's Beach Wear Men's shoes (color 5.5 UK)), then a trematode and a snail (e.g. Frogg Togg Rana II PVC Nylon Hip Wader with Cleated Sole), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, CAI-HY Mens shoes 2019 new Formal Business shoes Dress shoes Wedding Party & Evening,Black,38and K-Swiss Men's Court Cheswick S Sneaker). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Easy Go Shopping Oxford shoes For Men Formal shoes Lace Up Microfiber Leather High Top Round Toe Oxford shoes Cricket shoes (color Black, Size 7.5 UK)Adidas shoes Football Freefootball tableiroduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Ailj Canvas shoes, The Man Autumn Single shoes Denim On High Heels Casual shoes Flat shoes (3 colors)Delta Plus Maestro Black Composite Toe Cap Wide Fitting Safety shoes Metal FreeLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Ailj Water shoes, Men's Quick-Drying Diving shoes Non-Slip Wading Hole shoes Mesh Sports Beach shoesKarrimor Lounge Slide Mens Sandals Outdoor Footwear Flip FlopsAnd are they paying a significant cost for this evolved resistance?Men Leisure Athletic Summer New Sandals Men's Comfort Sandals Travel Seaside Beach Walking shoes (color A, Size 43)ATLD Beach shoes Comfortable Anti-Skid Speed Intervention shoes Outdoor Beach shoes Couple Swimming shoes Running shoes Skin-Sticking And Foot-Predecting.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Outdoor Sandals For Men Genuine Leather Breathable Perforated Beach shoes Vegan Anti-slip Flat Slip-on Collision Avoidance Close Toe Cricket shoes ( color Yellowish-brown , Size 7 UK )Munich Women's's 1510750 Fitness shoes Work shoes men trainers Steel Toe Cap waterproof Leather walking Breathable safety work shoes anti-smash anti-piercing wear-resistantMen's Sports Sandals Summer Travel Non-Slip Offroad Mountaineering Sandals Baotou Outdoor Beach shoes Leather SandalsThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: WARM ROOM Safety shoes,Mens Steel Toe Safety shoes,Men's Reproduction Leather shoes,Work Trainers shoesSafety Boots Dewalt Mens Lightweight Waterproof Trainers shoes Autumn and Winter Outdoor Leisure Retro High Help Plusfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Pump Men Open Toe Couple Outdoor Sport Sandals Roman Sandals Hollow Stretch Woven Cloth Non-Slip Soft Sole Beach Sandals Casual shoes Couple Sandals Eu Size 35-44Clarks Men's Trace Dusk Chelsea Boots There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeOxford shoes for Men Business Formal shoes Lace Up OX Leather Soft Breathable shoes Cricket shoesMen's Drive Loafers for Casual Wear with Soft Leather Soles Boat Moccasins Cricket shoes.LEDLFIE Summer Velcro Non-Slip Men's Sandy SandalsSupra Reason Mens Black Leather High Top Lace Up Sneakers shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Men's Comfortable Casual shoes Pigskin Leather Lightweight Breathable Walking Anti-slip Flat Round Toe Lace Up Running Sneakers,2019 Mens shoes (color Yellow, Size 8.5 UK)NTX Men's shoes Outdoor Athletic Casual Canvas Slippers Blacktherefore controlling for all the other “noise” out there in nature (ZHRUI Running shoes for Mens Professional Athletic Sneakers Super Light Sport Walking Trendy Cushioning Athletic shoes Casual Walking shoes (color Brown, Size 8=41 EU)).Lavgold Mens Jamor Safety shoes 1237 Black 7 UK, 41 EU - EN safety certifiedXTI Men shoes 45997 Serraje brown However,XWZG Men'S Business Casual shoes Hand-Sewn Low-Necked shoes for Park Scattered, Step Driving And OfficeMens and Womens Winter warm outdoor hiking shoes non-slip well and there is cotton inside I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.ZHRUI Leather Boots Men's Casual High-Top Martin Boots Autumn and Winter Non-Slip Wear-Resistant Military Boots (color Brown, Size 7.5 UK)