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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Y-H Men's Casual shoes, Spring Fall Walking Gym shoes, Student Flat Deck shoes Running shoes Travel shoes (color Black red, Size 44)The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Quiksilver Carver Suede 2 RT Mens Sandal Thongs BrownFila Maverick Men's Boots Black LOVDRAM Men'S Leather shoes Autumn And Winter Martin Boots Men'S Boots Leather Men'S Boots Plus Cotton Military Boots Fashion High To Help Men'S shoesChengzuoqing Men's Flip Flops Male Beach Home Casual Outdoor Abrasion Resistant Slippers for Multiple Cord Options Male and Female Models Beach Flip Flops (color Military green, Size 8.5UK)generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Munich Unisex Adults’ Gresca 08 Fitness shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Clarks Men's Prangley Walk DerbysVans Men's Old Skool TrainersWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Funtasma Men's Pimp-02 Closed-Toe SandalsJ.Bradford Derby Black Leather JB-ETAINGJLIANGXIE Men'S Sandals Beach Beach shoes New Men'S Summer Fashion Slippers Casual Beach Sandals Men'S Outdoor Vacation Sandals Beach SandalsConverse Low shoes Star Classic In Green Bottle Fabric 142392C I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Irish Setter Men's Traveler 3804 Oxford Boot, Tan, 11 2E US), then a trematode and a snail (e.g. ECCO Light III 810504, Men's Hiking shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Y-H Men'S shoes,Leather Spring Fall New Flat Loafers Soft Sole Comfort Driving shoes Loafers & Slip-Ons Office & Career,b,43and LLP LM Men's Peas shoes Casual shoes Leather shoes Driving shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Adidas Originals Stan Smith Trainers Black S75077TYX-SS Men'S Large Size Casual shoes Korean Business shoes Comfortable Driving shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Fashion Business Leisure Men's Leather shoes Leather Sets of Feet Flat HeelAmblers Safety Adult Unisex Footwear FS167 Leather Lace Up shoes Safety Work BootLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? FMWLST Boots PU Men'S Boots Autumn And Winter Casual Ankle Boots Lace-Up shoes Men'S Non-Slip shoesAdidas Men's's Men's FF Supersala Foot Wear-White bluee orange, Size 8And are they paying a significant cost for this evolved resistance?Jomos Alpina 5, Men’s BootsHNGLXQ Combat Boots G-69 Leather Side Zip Army Tactical Boots Delta Military Work Army shoes Safety Ankle Boots Breathable Commando Outdoor Desert Tactical Military Patrol Boots,Yellow-EU39.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).TYX-SS Men'S Business Casual Leather Men'S shoes Lightweight Lazy Driving shoesSnfgoij Work shoes Men Safety Sneakers Waterproof Lightweight Outdoor High Help Frosted Autumn Outdoor Retro Desert Boots Saucony Men's Shadow 5000 Vintage Low-Top SneakersTBS Men's Phenis D8 Boat shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Kenneth Cole Reaction Men's Zac Moc Toe Lace Up E OxfordNike - Mercurial Victory V - 651635760 - color Green - Size 9.5factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Men's Brogue shoes Lace Derby shoes Business Dress Casual shoes Fashion (color 1, Size 43EU)NIUMT Knight Men's Leather shoes, Gentleman shoes, Business Casual shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeWLFHM Men, Leather shoes, Rivets, Casual, Comfortable, Leather shoes, Single shoesCasual, Men's shoes, Spring, Business, Formal Wear, Leather shoes, Wedding shoes.Teva Men's M Terra Fi 4 SandalNew Balance Men's Summit Unknown Trail Running shoes At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Men's Formal Business shoes Summer Leather Breathable Hole Lace-up shoes For Casual Office Career OutdoorMen shoes Latin Modern Dance Genuine Leather Split Sole Soft Suede Sole Size 38To45therefore controlling for all the other “noise” out there in nature (Mens Tan Brown Two Tone Burnished Real Leather Vintage Smart Casual Italian Design Formal Oxford Lace up shoes).WDDGPZYDX Men shoes soft casual shoes Fashion male Comfortable sneakers Breathable summer shoes pour The FootwearFMWLST Boots Winter Men'S Suede shoes Men'S Sports shoes Outdoor Ankle Boots Men'S Casual High Boots However,XIE Pakamo Men's Leather Sandals Outdoor Trekking Hiking Climbing Fisherman Beach shoes With Velcro Lightweight Closed Toe Water shoesLambretta Mens Langham Gibson Lace Up Smart Leather Oxford shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Doggo Unisex Adults’ Maya Wellington Boots Brown