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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Adidas Men's Trainers white blueThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Rockport Men's Rocsports Lite Five Lace Up SneakerDeWALT Men's Carbon Boots Brown 8 UK YVWTUC Male colorful Basketball shoes Non-Slip Comfort Training SneakersSUN Hiking shoes Outdoor Casual Sports shoes Elderly Father 30-40-50 Years Old (color 3, Size EU41 UK7.5-8 CN42)generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Find. Men's Zip Classic Worker Bootsand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Geox U Federico Y Men shoes Lace-UpPieSanto Heeled shoes, Colour Grey, Brand, Model Heeled shoes 175552 GreyWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Cloud 9 Men's Lace-Up Flats Brown BrownZyuQ Ankle boots High-Top Men'S Boots Fashion Men'S Martin Boots In The Men'S shoes Short Boots Pu Tooling BootsQRETYSG flip flop Canvas Men Sandals Fashion Men Slipper Summer Beach shoes Men shoes Open Toe Slides Cork SlippersZ.L.F Men's Formal shoes Fashion Matte PU Leather Upper Slip-on Lined Oxfords Block Heel Oxford shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. KOKQSX-Sports shoes jogging running shoes autumn breathable mesh shoes), then a trematode and a snail (e.g. Military outdoor shoes for trekking hiking camping climbing professional tactical boots), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Ikon SLY Mens Leather Pointed Chelsea Boots Blackand Norton Neoprene Belly Predector Girth). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, ZHZNVX Unisex shoes Synthetic Spring Summer Fall Comfort Sneakers Running shoes Black,Black,US8 EU40 UK7 CN41Rockport Mens Total Motion Wingtip shoes in Brown- Lace Fastening- Tonalduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). YIXINY Europe Station Black Plate shoes Leisure Comfortable Youth Student Spring And Autumn (Size EU39 UK6.5 CN40)ASICS Unisex Adults' Gel Saga Low-Top SneakersLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? SELCNG Water shoes Barefoot Quick-Drying Water Sports shoes Outdoor Sports shoes Suitable for Kayaking, Boating, Hiking, Surfing, walking-green-41DZX Winter Outdoor Men's Non-Slip Waterproof Hiking shoes Warm Fur-Lined Snow Boots - For Camping, Hiking, Skiing Walking And Fishing,Men-Black-38And are they paying a significant cost for this evolved resistance?KAKAFASHION Men's Canvas Fashion Sports Trainers Boots Sneaker Trekking Hiking Footwear Lace-Up Loafer Flats shoes EU39-44LUCKY-U Men shoes, Men's Lightweight Sports Air Cushion Sport Running shoes Walking Hiking shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Fuxitoggo Mens Outdoor Sandals Walking shoes Water shoes Casual Sport shoes Fashion Breathable Net Quick Drying Beach shoes Upgraded Version (color bluee, Size 44EU)GHFJDO Men Outdoor Hiking shoes,Low-Top Lacing Up Water Resistant Sports Trekking Walking Running shoes WLFHM Men's, Casual shoes, Lace, 6cm Lace-up shoesMen British Leather shoes Fashion Lace Tooling shoes Casual shoes shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: INMONARCH Mens Cream and golden Wedding shoes MJ07986Sperry Top-Sider Striper Laceless, Unisex Adults’ Low-Top Sneakersfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.JIALUN-shoes Men's Pointed Single shoes Men's Fashion Oxford Casual Comfortable Simple Carved Breathable Brogue shoesXZB-shoes Men's Comfort Loafers Leather Spring Fall Comfort Loafers & Slip-Ons Yellow Light Brown Black bluee Dark Brown,C,45 There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeMizuno Synchro MX 2 Running shoes - AW17Zxcvb Autumn And Winter Men's Casual shoes High-top shoes Trend Martin Boots Warm Men's Boots Cross-border Large Size Men's shoes 39-46.Men's Running shoes Sport shoes Anti-Sliding mesh Breathable Cushioning shoes Leisure shoesshoes Men's cotton, plus velvet warm outdoor hiking non-slip sports walking Suitable for travel camping climbing At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, JUJIANFU-shoes Men's Comfortable Genuine Leather Moccasins Slip on Suede Insole Loafershoes Sandals Beach shoes Mens Sports Sandals Leather Walking Sandals Men's Outdoor shoes Ankle Strap Sandals 2 colors Outdoor shoes (color Black, Size 41)therefore controlling for all the other “noise” out there in nature (SRY-shoes Men's Comfortable Drive Loafers Casual Light Soft Leather Hollow Breathable A Foot Pedal Boat Moccasins (color Hollow White, Size 11 UK)).SeaVees Men's Army Issue Low Standard Casual SneakerEllesse Men's Ls-81 Bdg Trainers However,WWJDXZ Trainers Casual Men's Camouflage Fabric Sizes 24.5cm to 27.0cm bluee Four Seasons Wearable Board shoes SneakerT.U.K VLK D Ring Creep Sneak Blk SDE Wht Int, Unisex Adults’ Low I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Men's Waterproof Hiking Boots, Trekking Outdoor Sneakers Climbing Sports Breathable shoes