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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Sunshine-Family 2019 Rex Slippers Fluffy Slides Fuzzy Sliders Soft Plush Fur Mules Summer shoes Women Furry SlippersThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Niliyou Slip On Flat Sandals String Bead Beach Big Size Women Flip Flops Summer shoesZerenQ Ankle Strap Sandals for Women Stiletto 6cm High Heeled Pumps Side Cut Pointed shoes for Ladies (color Black, Size 33 EU) CHALi99 Fashion Women Lightweight Mesh shoes Tropical Leaves Navy bluee Birds Pattern Sneakers Workout Quick DryCHALi99 Womens Lightweight Mesh shoes Tropical Leaves Green Watercolor Palm Leaf Sneakers Running Soft Solegenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, 2019 Summer Fashion Chunky Sandals Platform Beach Sandals Leather Comfortable Casual,Black,8.5and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Soulength Women's Hollow Pumps Breathable Stiletto Sandals Fashion Point Toes shoesCHENSF Women's Clear Strappy Wedges High Heels Platform Roman Sandals shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,ASHIJIN Women Bag Handbag Messenger Bag Shoulder BagsRhinestone Ear Fox Fur Slippers Sweet Woman Slippers Closed Outdoor Women SlippersSpring Warner Heart Star Bear Line Print Sneakers Personalized Design Walking shoes Casual Women Lightweight Breathable Non-Slip shoes ERU36-41Odema Women's Winter Boots Slip On Velvet Snow Boots Suede Flat Platform Sneaker shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Woman Sandals Women shoes Rhinestones Chains Thong Crystal Flat Heels Comfortable Sandals), then a trematode and a snail (e.g. Tiwcer Summer Flip Flops Women Slippers Leisure Female Ladies Beach Outdoor Casual shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, ASHIJIN Multicolor Woven Circular Round Bags for Women Night Clutch Chain Shoulder Bag Handbagand ASHIJIN Bright Yellow Crystal Night Clutches Woman with Rhinestones Bridal Wedding Party Bags Clutch Bag Shoulder Bags Bag). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, DoraTasia Women's Fashion Sweet PU High Heel Bowtie Pointed Toe Stiletto Platform Dress PumpsWHW Women shoes light port Single Twine Bow Knot ,green,37 shoes tipsduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Brianna Leigh Women's Flower PumpWomen shoes Pointed Toe Pumps Dress shoes High Heels shoes Wedding shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Women Pumps Leaf Flame High Heel Pumps shoes for Women Sexy Peep Toe High Heels Sandals Party Wedding shoes WomanJQSM Arrival Nubuck Pu Leather Handbags for Women Casual Female Shoulder Bag Crossbody Bag Ladies Large Rivet Messenger BurgundyAnd are they paying a significant cost for this evolved resistance?Women Sandals Summer Flat Pearl Sandals flip Flops Rome shoes String Bead SlippersWomen's Classic Chunky Heel Ankle Booties Lace up Round Toe Slip-On Handmade Platform Oxford shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).CuriousLady-sandal Womenals Slip-on Flat Platform Comfortable Flower shoes Black Pink,Sand Pink,39Heels Sandals high Women Wedges Crystal Causal shoes Super High shoes Sandals Patchwork Open Toe shoes Bohemia Anti Skidding Square Heel SlippersDoraTasia Women's High Heel Ankle Boots Summer Sexy Pointed Toe Transparent Sandals Boots Roman Dress shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Jidngc Big Size 44 Women shoes Comfort Sandals Summer Flip Flops Flat Sandals Gladiator SandaliasDoraTasia Women's Concise Peep Toe Ankle Buckle Strap High Heel Platform Sandalsfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Linson123 Women's Canvas shoes Personality Fashion Metal Zipper Women's shoes Casual shoesUranus gold Clutch Purse for Women Ring Handle Satchel Crossbody Evening Bags Handbags Casual Crossbody Bag There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeWomen's Closed Toe Ankle Strap Block HeelCHENSF Woman Wedge Sole Velor Low Heel Lightweight Business Office Ceremony shoes Easy to Walk.Huhuj End of Summer Jelly shoes Gladiator shoes Boots Low Student shoesSneakers 2019 Summer Outdoor Flats Sneakers Ladies Casual Woman Slippers White Sneakers Women At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Women's Fighting Buckle Strap Side Zipper Tactical Impossible Complex Design Ankle Boots shoesINSTANTARTS Puppy Dog Printing Running shoes for Women Flat Athletic Trail Sneakertherefore controlling for all the other “noise” out there in nature (Willie Marlow New Summer Beach Cork Slippers Casual Double Buckle Clogs Slides Women Slip On Flip Flop shoes Plus Size).INSTANTARTS Galaxy Fashion Sneaker Sport shoes Women Walking Running Mesh FlatDoraTasia Women's Summer Pu Sexy Pointed Toe Closed Toe High Chunky Heel Sandals Ankle T-Strap Buckle Sandals However,Water Sport shoes for Women Beach shoes Woman Sock shoes Lightweight and BreathableBea-life Women Casual Flat shoes Classic Female Loafers Weave Ladies Pointed Toe Footwear I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.DoraTasia Women's Fashion Pointed Toe High Heels Ankle Warp Cloth Pumps shoes