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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Feenfling Citrus Lemon Graphics Womens Light Canvas Tennis shoes Low Top Fashion Athletic Sneakers for Women'sThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Watercolor Beach Surfing Patterns Womens Fashion Slip on Low Top Lightweight Canvas SneakersBrilliant sun Women's Elegant Buckle Slip Sliders Mule Sandal Low Heels Mule Foxy Forest Fall Pattern Fashion Canvas Sneakers For Womns 3D Printed Low Top shoesWomens Low-Heeled Sandal shoes Summer Flat Heel Single shoes Female Slipper Sandals Hollowing Out Women's shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, HCHBE& 2018 New Spring Autumn high top Platform Girl's Canvas shoes Zipper Fashion Women Casual shoes Female Leisure shoes Sneakers color 1 6and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Ladies Slippers Size EU 37 38 39 40 Comfort Fluffy Cute Warm Hourse Slippers Pink Non-Slip Sole Indoor Bedroom SlippersLifeStride Womens Joelle Ankle BootWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Women Ballroom Dancing shoes Salsa Sandals Latin Dance Practice shoes Ladies Dancing Rumba Waltz Prom shoesGusha Women's Embroidered Booties Thick Ankle Boots Side Zipper Martin BootsFG21ds21g shoes Holders for Sandals Heels Casual shoes SneakersLittle Happiness Women's Boots Women's shoes high Boots After Sanding with Tassels Sleeves Wedges Snow Boots I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. KAOKAOO Winter Boot Flower Decoration Boot Snow Boot for Women Girl), then a trematode and a snail (e.g. Super frist Women Ankle Boots Rubber Rainboots Floral Printed Waterproof Rubber for Garden Women Rain Footwear), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Feenfling Cute Good Night Moon Womens Casual Slip on Low Top Canvas Volleyball Sneakersand Illustration Drawing Eye Pattern Womens Fashion Slip on Low Top Canvas Tennis shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Women's shoes Slippers Plush Fashion Casual Outdoor Home shoesAthena Alexander Womens Stormm Dress Pumpduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Women shoes Flip Flop Sequin Decor Bohemian Muffin Slope with Summer Beach SandalsFAAERD Women's Fashion Lightweight Running Sneakers Cheeseburger Cats Burger Clouds Double Food colorful Tennis shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Women's Fashion Lightweight Sneakers Cute Poodle Pattern Retro Boat shoesWomen's Fashion Lightweight Basketball Sneakers Branches Pattern Original Boat shoesAnd are they paying a significant cost for this evolved resistance?Feenfling Veg Pizza Party USA Pizza Womens Navy Slip on Low Top Canvas Tennis shoesFeenfling Cute Cartoon Squirrel with Nuts and Autumn Leaf Womens Casual Slip on Low Top Canvas Athletic Sneakers.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Feenfling Cute Corgi Head and Beautiful Flowers Florals Womens Denim Slip on Low Top Canvas Tennis shoesFeenfling Crab Fun Hipster Pattern Womens Navy Slip on Low Top Canvas Deck shoes Women's Fashion Lightweight Tennis Sneakers Abstract Floral Teal Olive Rendy Gym shoesWomen's Fashion Lightweight Tennis Sneakers colorful Zebra Stripe colorful Walking shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Fashion Sneakers For Women Watercolor Summer Kiwi Original Lightweight Breathable Mesh Womens Gym shoesFashion Sneakers For Men Cartoon Buho Cute Owl Pattern Original Lightweight Breathable Mesh Mens Sneakers shoesfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Feenfling Cute Cartoon Dachshund Christmas Womens Plain Slip on Low Top Canvas Tennis shoesBtrada Women's Flower Thong Flip Flops Summer Anti-Slip Wedges Clip Toe Beach Slippers Fashion Sandals There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeFloral Sea Turtle Light Green Womens Flat Canvas Running shoes Low Top Popular Sneakers shoes for Women'sFeenfling White Pink Unicorn Sunflowers Womens Latest Sneakers shoes Low Top Cute Cloth shoes for Women Girls.Fashion Sneakers shoes For Men Christmas Ringbell Candy Tree Print Lightweight Breathable Mesh Mens SneakerBohemia Wind Toe Clip Slope with Ladies Sandals Handmade Beaded Comfort Toe Clip Sandals Wedge shoes (color Khaki, Size 39) At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Feenfling Penguin Classics bluee Womens Navy Canvas Running shoes Low Top Fashion Sneakers for WomanFeenfling Tropical Jungle with Flamingo Womens Flat Canvas Tennis shoes Low Top Cool Sneaker for Women'stherefore controlling for all the other “noise” out there in nature (Feenfling Evil Screaming Skull Womens Flat Canvas Deck shoes Low Top Cute Volleyball Sneakers for Women).Feenfling Cute Cat Face and Paw White Background Womens Navy Canvas Low Top Hip Hop Sneakers for WomanFunny Cats Womens Denim Canvas Lace up Dhoes Low Top Best Sneakers shoes for Woman However,Simple and Stylish Shallow Mouth Pointed Low Help high HeelsBigcardesigns Lightweight Running Sneakers Personality Printed Lace-ups Gym Fitness Trainers for Women Men I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Feenfling Classical Music Violin Womens Plain Suede Canvas Boat shoes Low Top Sneakers shoes