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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. MKJYDM Patent Leather Business Dress shoes Men's Casual shoes Classic Wedding shoes Fashion Pointed shoes 38-44 Yards Men's Leather shoes (color Black, Size 40 EU)The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Men's Ankle High Round Toe Popular Leather Chukka Boots Genuine Leather Martin Boots Desert Army Military Boots Lace ups,Black(Cotton),46CHENXD shoes, Men's Casual Low Top Round Toe Business Oxford Soft Light Gentlemen Atyle Formal shoes Ino Durable Driving Loafer for Men Boat Moccasins Slip On Style PU Leather Elastic Design Low Top Solid colorMen's PU Sandals Convenient Velcro Leisure Non-slip Beach shoes Cozy Breathable Latex pad Dual use Outdoor shoes,Khaki,42generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, CHENXD shoes, Men's Classic Crocodile Round Toe Business Oxford Casual Simple Formal shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Good-Memories Men Vintage Combat Winter Cow Split Leather Waterproof Buckle Military BootsVans Authentic(TM) Core Classics (41 M EU 10 B(M) US Women 8.5 D(M) US Men, Black (Black White))We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Reebok Phase 1 PRO MU - Footwear Men's Footwear Men's Lifestyle shoesNunn Bush Men Moccasin Toe Oxford Lace Up with KORE Comfort Walking Technology, Bone, 10Men's Leather Sandals Men's Casual shoes Travel SandalsMens Walking Sandals Leather Open Toe Outdoor Sports Beach Sandal for Hiking Trekking Traveling, Ankle Strap,Brown,40 I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Hitz Mens Formal shoes Pine 3308), then a trematode and a snail (e.g. Serfas Men's Paceline 3-Strap Road Cycling shoes - SMR-401W), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, MOZOEYU Men's Mesh Athletic shoes - Perfect for Cycling, Mountain Climbing & Casual Walkingand PY Men's Chocorua Trail Mid Waterproof Hiking Boot). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, CHENXD shoes, Men's Punk Style Non-Slip Rubber Sole shoes Smooth PU Leather Slip-on Lined Oxfords Prom Loafer with Rivets BlackCHENXD shoes, Men's Fashion Comfortable Oxford Casual Slip On Cowhide Leather Formal shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Sandals Slippers Summer Men's Leather Flip Flops Er Thick Slip Slippers Comfortable Slippers Fashion Trends(color )(Size )Men Boots Army Waterproof Boots Men's Motorcycle Martin Mid Heel Steampunk shoes Motorcycle Western Cowboy Boots Uniform Boots,43Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Vans Men's Authentic Sport Pop Ankle-High Canvas Fashion SneakerIno Sandals for Men Fashion Slipper shoes Slip On Style Microfiber Leather Metaldecor Double PurposeAnd are they paying a significant cost for this evolved resistance?Nike Men's Flex Show Tr 5 - Footwear Men's Footwear Men's Running shoesSupra Men Skytop (Black Tawny Pristine).
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Funtasma by Pleaser Men's Halloween Clown-02,bluee Red,one S (US Men's 8-9 M) IZEMen's Fashion Men's Outdoor Non-Slip Casual shoes Men's Cool shoes Sandals Men's Beach shoes Work Boots，shoes Hiking shoes for Men's Outdoor Sport Beach shoes Trekking Sandals Mesh Lightweight Trail Running shoes Quick Drying Water Sneaker CampingCHENXD shoes, Men's Brogue Pattern British Style Oxfords Flat Heel Lace up Leisure shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: CHENXD shoes, Men's Breathable Lined Oxfords Low Top shoes Casual Matte Genuine Leather Lace Up LoafersCHENXD shoes, Men's and Women's Casual Wind Driving Loafer Super Fiber Leather Large Size Breathable Boat Moccasinsfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Williess Leather Casual shoes Men's Toe Leather shoes Lazy shoes (color Khaki, Size 43)shoes for Men or Women hyx Comfortable and Breathable Non-Slip Set Feet Outdoor Hiking Sneakers Formal shoes for Men, shoes Size 40 (color Brown) There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeMen's Hiking shoes Sandals Outdoor Sport Casual Anti-Skid Beach shoes Cross Country shoes for Trekking Walking Mesh Breathable Sneaker Water shoesCHENXD shoes, Men's Fashion Genuine Leather Driving Loafers Strap Decor Slip-on Leisure Penny Moccasins Soft Rubber Sole.HWUED Fashion,Stylish Sweet Candy and Cola Canvas shoes Low Top Print Lace-up Classic Sneaker for Men WomenIno Monk Strap Oxfords for Men Brogue Carving Low Block Heel Microfiber Amphetamine Punctured At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Men's Plus Velvet Boots, Men's Leather Martin Boots Men's Casual shoesMen 's Home Slippers Indoor Keep Warm Leisure Artificial Leather Slippers Black Soild color Bedroom Mediumtherefore controlling for all the other “noise” out there in nature (JaHGDU Men's Cotton Slippers Faux Leather Keep Warm in Autumn and Winter Home Casual Slip Thick Soled Slippers for Men Brown).IGI&CO 3132722 Sneakers shoes Man Made of Memory Foam Leather Made in Adidas Predator Tango 18.1 shoes Men's Soccer 9 Black-White-Red However,CHENXD shoes, Men's Fashion Lace up Pointed Toe Business Oxfords Casual Low Top Leisure shoesCHENXD shoes, Men's Fashion Personality Oxford Casual Comfortable Rivet Slip On Patent Leather Formal shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Vans Mens Chukka Low Pewter White Gum