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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Casual shoes Summer White shoes Men's Sports Wild Tide shoes Flat Breathable Casual shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Flying Woven shoes Mesh shoes Sneakers Casual shoes Thick Soles Men's Trend Running shoesYJ-Print Mens Womens Work Safety shoes,Breathable Outdoor Steel Toe Footwear Industrial and Construction shoes,Birthday Present from Daughter,Son,Wife CHENXD shoes, Men's Comfortable Low Top Business Oxford Casual Simple Pure color Slip On Formal shoesLeather Autumn Men Boots Winter Waterproof Ankle Boots Martin Boots Outdoor Working Boots Men shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, USB Charging shoes Luminous shoes Ghost Dance LED colorful Lighting shoes (color A, Size 44EU)and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Perry Ellis Mens Flannel Plaid Moccasins Slippers (XL 11-12, Green)Aquatalia Women's Falco Suede Chelsea Boot Navy 11 M USWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,CHENXD shoes, Men's Fashionable Design Round Toe Ankle Boots Block Heel Pull On Slouch Vamp Oxfords shoesWilliess Sports shoes Men's Breathable Non-Slip Wear Men's Casual shoes Men's Tide shoes (color Black and red, Size 42)Sam Edelman Women's Bonnie Slingback SandalAravon Women's REVsavor Flat,Navy,9 D US I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Ino Fashion Sneaker for Men Sports shoes Slip On Style Canvas Troll Toe Outside Leisure Trend), then a trematode and a snail (e.g. Men's Outdoor Sneakers for Mountaineering Hiking Climbing Trekking Running shoes Lace ups Off-Road Sport Mesh Footwear), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, CHENXD shoes, Men's Genuine Leather Casual Driving Penny Loafers Slippers Slip-On Boat Mulesand Cycling shoe cover Womens Mens Outdoor Sports Cycle Rainstorm Snowstorm Motorcycle Bike Garden Rain Gear Flat Overshoes Waterproof Overshoes Rain shoes Covers Black Anti-slip Reusable Zippers Boot Cove). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Indian Wholesale 50 pc lot Bulk Mandala Ombre Hippie Assorted Bag Tribal Boho Shoulder & Handbag Ethnic Cotton Messenger Carry Bag With Shoulder Strap Tote Purse For Ladies by Craft Place CAD-85Indian Wholesale 50 pc lot Bulk Mandala Hand Bag Ethnic Clutches Purse Shoulder Assorted for Ladies by Panchal Creation-37during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Ariat Women's Circuit Salem Western Boot, Naturally Distressed Pink, 6.5 B USASICS Women's Gel-Nimbus 19 Running shoes, Diva bluee Flash Coral Aqua Splash, 8 D USLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Julian Hakes Women's London Lepard Yellow Mojito shoesAdidas Women's a3 Transfer Running shoesAnd are they paying a significant cost for this evolved resistance?Glowing shoes Charging colorful Lights Led shoes Ghost Dance shoes shoes Couple shoes Sweat-Absorbent Breathable (color A, Size 39EU)CHENXD shoes, Men's Retro Brush color Round Toe Business Oxford Casual Lace Flat Formal shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Sandals Outdoor Fisherman Sandals Fashion Sandals Casual Sports Simple Lightweight Convenient Hook and Ring Outdoor Water shoes (color Brown, Size 7.5 D(M) US)Air Cushion Running shoes Men Breathable Runner Athletic shoes Sneakers Panchal Creation Wholesale 50 pc lot Bulk Indian Vintage Hand Bag Traditional Bridal Clutch Beaded Shoulder Bag potli Pouch Hand Bag Purses Women Purse by Craft Place M -36Indian Wholesale 50 pc lot Bulk Mandala Hand Bag Ethnic Clutches Purse Shoulder Assorted for Ladies by Panchal Creation-39The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Ecco Women's Biom Lite TrainersBernie Mev Women's, Catwalk Slip-on shoes SPLASH 3.8 Mfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.CHENXD shoes, Men's Synthetic Leather Business Brogue Carving Modern Wingtip Lace Dress shoes Fashion Casual Flat Lace Up Round Toe Low Heel LoafersSandals Sport & Outdoors Dynamic Men's Summer Open Toe Casual Cool shoes Beach shoes Dad Leather Trends(color )(Size ) There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeMen's Office Business Casual Oxford shoes Black Brown 37-48GYYFC Men's Non-Slip One Word Slippers Leisure Rivet Reinforcement Beach shoes Convenient Breathable Massage Sandals.Dr. Scholl's shoes Women's Behold Ankle Boot, Black Smooth Snake Print, 9 M USCobb Hill Women's Ainsley Black sandals 7 M At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, FH Hiking shoes Cross-Country Running shoes Men's Outdoor shoes Non-Slip Wear-Resistant Hiking Low-top shoesHWUED Fashion,Stylish Cartoon Comic OMG Pop Art Canvas shoes Flat Print Lace-up Classic Sneaker for Men Women 43 Blacktherefore controlling for all the other “noise” out there in nature (Spearss LightweightMens Sport Leather Teens Boys Basketball Running shoes Convenient).Hi-Tec Men's Mokala Mid Light Hiking BootMen's Outdoor Casual Beach Sandals Baotou Anti-Collision Breathable Men's Sandals (color Black, Size 43) However,Women's Sandals Suede high Heels Fish Mouth Open Toe Metal shoesJ. Renee Women's Bambalina Pump White Lizard Print Patent Leather Size 7 WW I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.CHENXD shoes, Men's Fashion Personality Print Texture Light Oxford Casual Comfortable Low top Loafers