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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Khaki XWQXX Tactical Hiking shoes Men Breathable Non-Slip Summer Low-top Combat Boots Wild Walking shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Fleece Inside Black Fuxitoggo Men's shoes Side Zipper Lace Up Leather Upper Mid Calf Fight Martin Boots for Men (color Fleece Inside Black, Size 42 EU) (color Fleece Inside Black, Size 37 EU)Black snfgoij Safety shoes Men Sneakers Waterproof Resistant Outdoor Martin Boots Leather Plus Velvet Ankle Boots Retro Large Size A YongBe Men's Black Smart Office Work uniform Derby Men Wedding Party Dress Loafer Flats Business Leather Lace-Up Oxford shoesBlack Leather shoes Men's Wild Feet Peas shoes Business Driving shoes Men's Casual shoes Cricket shoes (color Red, Size 42)generating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, White Men's And Women's Running shoes Casual shoes Fashion Wear Lace Light Couple shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Brown Fluchos Men's Choi DerbysBlack AEYMF Spring Brogue shoes British Style Men's Leather shoes Casual shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Navy Red Sperry Top-Sider Men's Striper II Slip-On Sneakerbluee (bluee Ftwr White) adidas Men's Powerlift 4 Fitness shoes- Onitsuka Tiger ASICS - Mens Mexico 66 Slip-on shoes, 4 UK, White WhiteBlack (black 100) Bugatti Men's K29351g3 Desert Boots I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Olive Fila Men's Grunge Mid Hi-Top Trainers), then a trematode and a snail (e.g. White (Wsl) Skechers Women's Flex Appeal 2.0-Good Time Fitness shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Green (Light Pumice Light Pumice Mica Green 009) Nike Men's Presto Fly Se Gymnastics shoesand Grey Lumberjack SM30405-011 Sneakers Man). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Nightshade Lloyd and Pryce Altrad- Arcibold Fashion Botin Campero napa Black Man Johnny Bulls EN-GBduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Black LYMYY Men's shoes Men's Boot High-top Leather Ankle Boots Lace-ups Martin Boots Casual Chelsea Boots Trekking Hiking Footwear,Coffeecolor,43EUBlack SRY-Fashion shoes 2018 New Men's Fashion Ankle Boots Casual Winter Comfortable Fleece Inside Warm High Top Boot(Conventional Optional)Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? B GanSouy Men's Black Leather Lace-Up shoes Wedding Formal Dress Oxfords Brown Business And Daily Wear Work Office Low-top Derby shoesBrown (Rum Kombi 54) Think Men's Zagg_282601 BroguesAnd are they paying a significant cost for this evolved resistance?Black (Black Red Black Red) Vibram FiveFingers Men's Kso Evo Fitness Multisport Indoor shoesAll-over Black Nautica Men's Casual Lace-Up Fashion Sneakers Oxford Comfortable Walking shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Grey (Grey Two F17 Ftwr White Gum 3 Grey Two F17 Ftwr White Gum 3) adidas Men's Gazelle Gymnastics shoesgrey Josef Seibel 13851-MA768 Jonas 01 Moccasin Boots ShopSquare64 Men Hole Lace Up Sandals Summer Beach Slipper shoesSkechers Mens Go Meb Razor 2 Charcoal Lime 10 D - MediumThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Propet Men's Logan Slip On Sneakers, Grey Nubuck, Nylon, Polyurethane, Rubber, 10.5 MHWG-GAOYZ shoes Men's Martin Ankle Boots Footwear Winter Outdoor Plus Velvet Hiking Hiking Boots Warm,DarkBrown-44factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.bluee adidas Men's Stabil Bounce Handball shoesBrown (Castagne-kombi 351) Josef Seibel Men's's Chance 39 Combat Boots There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeWhite Fred Perry Men's Horton Canvas SneakerMulticolour (Team Crimson Team Crimson White 606) Nike Unisex Adults Zoom Stefan Janoski Fitness shoes.Creative Recreation Men’s C Cesario Lo XVI Low-Top SneakersTOTO Men's Invisible Height Increasing Elevator shoes - Black Leather Lace-up Lightweight Casual Trainer Sneakers - A019-2.8 Inches Taller At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, White Silver K-Swiss Mens St-329Navy bluee adidas Men's Superstar Supercolo Trainers White Whitetherefore controlling for all the other “noise” out there in nature (Mint Saucony Women's Shadow Original Low-Top Sneakers).Charcoal Baffin Mens Zone-M Zone-mWhite (White Black Aluminium Barely Volt 100) Nike Men's Air Max Axis Prem Running shoes However,Puma Men's Rs-0 Ai Circuit Board SneakerDockers by Gerli Men's 35ca013 Ankle Boots I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Black gold & Gravy Men's Puff Loafer