- - Nike AIR Jordan 1 MID SE - 852542-306
- CLEBAO Fashion, Contrast, Korean, Wild, Chain, Shoulder, Crossbody, Small Square Bag
- Natural Cobblestone Health Massage Slippers Foot Acupoint Health Massage Slippers (color RED, Size 41)
- ZX Boots Women's Twisted Rider Fashion Boots
- An Meng Xin Ling Peep Toe Heels Women Platform Leather High Heel Slip On Stilettos Sexy Red Wedding Bride shoes Dress Comfort Plus Size
- Anti Theft Water Resistant College School Bookbag,Casual High School Backpack fits 15 in Laptop (hkaki)
- Women Ankle Boots Thin High Heel Zipper Bowknot Pointed Toe Black Party Elegant Ladies shoes
- LingGT Soft Ankle Leather Buckle Black Flat Boots for Women (color Black, Size CA 6)
- Men's shoes Men's shoes, High-top Mens Military Boots Large Size Fashion Winter Training shoes Security shoes Trend Combat Boots Outdoor Leisure Men's Fashion Boots (color B, Size 39)
- NIUMT Trend, Fashion, Geblackus, Lightweight, Pointed, Comfortable, Men, Small Fresh
- Gcanwea Women Snow Boots Wool Blend Patchwork Warm Winter Boots Girls Mid Calf Botas Sneaker Boots Big Size Elegant for Girls Fashion Comfortable Easy to Match for Woman Black 4 M US Boots
- Women's Sandals 2019 New Stiletto High Heels Patent Leather Wedding shoes Fashion Pumps Novelty shoes gold,A,36
- Spring Step Patrizia Trinket White Leather Sandal US 9.5-10 EU 41
- Converse Chuck Taylor All Star Low Top Suede Mono color purple Purple
- Merrell Around Town Chukka Air shoes
- POJ Maiko Geisha Wooden Sandals of Japan [ 8US Size for Women ] Japanese Kimono Cosplay
- Comfortabel Damen-Sling Ballerinas brown (2)
- O-NEX Onex Women's Modest Dress Sandal
- Aquatalia Womens Francoise Calf Mule
- HAOXIAOZI Genuine Leather Men's Casual shoes Driving shoes Comfortable Set of shoes Wearable Men's shoes
- Azurite Jessica Simpson Women's Dalyn
- RuNNex 5101-48 Safety shoes Team Star , S1, Size 48, black orange - EN safety certified
- PUMA Men's El Ace 2 Leather
- Nike Men's Niike Air Force 1 Pe (gs) Basketball shoes, (Black White 000), 6 UK
- Georgia Men's Zero Drag-M Steel Toe Work Boot, Brown, 11 M US
- 2018 Fashion Women Autumn Winter Classic Zipper Snow Ankle Suede Warm Fur Plush Boots
- KingRover Women's Trendy Open Toe Studded Block Mid Heels Rivet T-Strap Sandals
- Karl Conner Cow Genuine Leather Sandals Women Flat Heel Sandals Fashion Summer shoes Plus Size
- Newnorthstar Sneaker Women Sports shoes Air Cushion Female shoes Breathable Women Fashion Women's shoes
- Wallhewb Women Fashion Platform Sneakers Femael White Casual Black shoes Soft Joker Wear Resistant Elegant Beautiful Fashionable Black 7.5 M US shoes
- The Original Comfort Bed Socks - Baby Pink - Anti Skid
- AdeeSu Womens Casual Warm Lining Solid Urethane Boots SXC03711
- Chunky Motorcycle Boots for Women Autumn Round Toe Lace-Up Combat Martin Boots
- BESTON EJ27 Women's Elegant Inner Zipper Wrapped Chunky Heel Ankle Booties
- Alpargatus Espadrille Stripes 6 Colours
- T-JULY Fashion Women Winter Flat Boots Fabric Stretch Cow Leather Low Heel Over The Knee Long shoes
- Adrianna Papell Women's Prince Oxford Flats
- English Laundry Mens Grove Sneaker
- ECCO Men's Harold Plain Toe Oxford
- MINIVOG Women's Simple Style Leather Vamp Pointed Toe Knee-high Martin Boots
- EileenFisher Womens Ann-nu Dress Sandal
- Miaozaigou MZG Female pointed high with shallow mouth fine with red Wedding shoe patent shoes
- Fuxitoggo ShuMocassini Mens 2018 Mens Mens Moccasin shoes for Moccasins, Casual, Comfortable, Handmade, Trend, Thongs, Boot, Moccasin 38 EU Yellow (color Black, Size 39 EU)
- Nike Men's Mercurial Victory VI FG Black White Electric Green Soccer shoes
- FMWLST Boots Autumn And Winter Men'S Boots PU Men'S shoes Casual High Cut Lace Winter Warm Non-Slip Boots
- FRYE Men's Harness 12R, Gaucho, 8 W
- Bordeaux Soft Vintage Leather Frye Women's Melissa Button Boot
- CHENSF Women's Classic High Handle Waterproof Insulated Rain Boots
- Gjsonmv Cat Kitten and Butterfly mesh Lightweight shoes for Women Non Slip Sports Walking Sneakers shoes
- Madosh, New Genuine Leather Women's Bag Vintage Shoulder Sling Crossbody Bag Purse Brown
- AllhqFashion Women's Imitated Suede Round-Toe Kitten-Heels Solid Pumps-shoes
- Eoyles gy Cactus Balloons Plants Women's Slip Resistant Lightweight Running shoes
- Natural-Breeze Elite-01 Women's Chunky Heel Tassel Lace up Side Zipper Suede Ankle Bootie
- blueeberry Pomegranate Woman's New Sports Running shoes Navy colorful
- Gola Women’s Coaster Blossom Off White Trainers
The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Kyle Walsh Pa Flip Flops Flat Sandals for Women,Summer Boho Tassel Pompom Beach Slipper shoes BrownThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,New Balance Women's PureAlign Slide SandalJocbinltd Elegant Women shoes Bowtie Flat shoes Loafers Pointed Heels shoes Ladies Flats European Footwear Wine red TDA Women's Lace-up Comfort Mid Heel Lace Mesh Appliques Tango Salsa Latin Modern Dance shoesUnm Women's Simple Burnished High Heel Pumps - Pointy Toe Low Cut Stilettos - Slip On Wear to Work shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, HANBINGPO 2019 European Station Sandals Candy color Luxury Rabbit Fur High Heel Sandals Slippers Large Women shoes Size 35-43,Pink Rabbit,9.5and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Ellie shoes E-623-Craze 6 Heel Wedge Sandal.SJJH Women Pumps with Low Heel and Pointed Toe Casual shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
American Grown Guyana Root Women'S Casual Canvas Handbag For Shopping Shoulder Tote
I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Welcometoo 2019 Hot Plus Size Elegant Women Foldable Flat shoes Fashion OL Ladies Flats Round Toe Woman's Footwear Female A074Sperry Women's Seaside Nautical Perf shoesSwedish Flag Women'S Recreation Canvas Handbag For Shopping Big Shopping BagScience It's Like Magic But Real Women'S Leisure Canvas Sling Bag For Work Handbag I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. New Candy color Women Pumps Shallow color Block Thick High Heels shoes Bowtie Pink Working shoes), then a trematode and a snail (e.g. AdeeSu Womens Cross-Body-Strap Platform Height Polyurethane Sandals), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Flats shoes Women Ballet Princess shoes for Casual Crystal Boat shoes Rhinestone Women Flats Plus Size Newand Meimeioo Women's Ballet Flats Comfort Soft Slip On Square Toe Dress shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, American Flag German Map Women'S Recreation Canvas Shoulder Bag For Shopping Big Shopping BagLGBT Rainbow And Transgender Pride Flag Heart Women'S Casual Canvas Shoulder Bag For Work Shoulder Toteduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Flag Map Of Washington Women'S Casual Canvas Shoulder Bag For Work Shoulder ToteElk Galaxy Women'S Leisure Canvas Sling Bag For Travel Big Shopping BagLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Eiffel Tower Paris Frence Women'S Recreation Canvas Sling Bag For School Big Shopping BagPuerto Rico Flag1 Women'S Casual Canvas Sling Bag For Shopping Work BagAnd are they paying a significant cost for this evolved resistance?AdeeSu Girls Comfort Formal Open-Toe Polyurethane SandalsEllie shoes Women's 601 Juliet C Platform Sandal.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Womens Nike Free 5.0 TR FIT 4 PRTNafanio Winter Slippers Cartoon Squinting Dog Soft Plush Women Indoor Floor Warm Bedroom Big Size Home shoes Cute Pugs Women'S Casual Canvas Shoulder Bag For School Big Shopping BagTexas USA Flag Heart Women'S Recreation Canvas Shoulder Bag For Travel Work BagThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Is My Bike Ok-1 Women'S Casual Canvas Sling Bag For Travel HandbagGherkin Women'S Recreation Canvas Shoulder Bag For Work Handbagfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.HANBINGPO Bling Women Sandals Summer Fashion High Heel Sandals Crystal Casual Ladies shoes High Heels Rhinestone Slippers Q409,bluee,7Skechers Womens Bobs Plush - Kitty Jam Flats There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeGilesJones Flats Loafers Women,Summer Hollow Round Toe Lace up Moccasins Ballet shoesSmile-bi Women Boots 2018 Winter shoes Women Plus Insole Snow Boots Fur Ankle Boots for Women.CoolBao Women Canvas Round Toe Lace up Flat Canvas shoes Oxford Boat shoesRob-Zombie- Classic women's Canvas Slip-Ons Loafer shoes Sneaker At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, ADELINA Women's Floral Patterned Boat Loafer shoes Driving Moccasin 39-Black 40 EU 8.5-9 USEdv0d2v266 Women Casual shoes Breathable Height Increasing Sneakers Fashion Swing Shake shoestherefore controlling for all the other “noise” out there in nature (Women Boots Mid-Calf High Wedge Heel Warm Fur Soft Female Winter Snow Botas).QARYYQ Rain Boots, Rain Boots, Men's and Women's shoes, Waterproof, Rain, Anti-Skid, Wear-Resistant, Thickened, Snow-Proof Outdoor Bicycle shoes Cover (color White-2pair, Size XL)Northside Womens Pioneer Wp-w Hiking Boot However,Crazy-Shop Winter Over The Knee Boots Women Thigh High Sexy Lace Up Woman Flat shoes Long BotaHANBINGPO Gladiator Bohemian Sandals Women Crystal Summer Slipper shoes Women Flatshoes Flip Flops 2019 I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Unm Women's Vintage Peep Toe Heels shoes