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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Men'S shoes, Leather Moccasins Peas shoes Loafers & Slip-ONS Loafer Boat shoes Driving shoes Casual shoes Flat shoes Business shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,VALLEgreen shoes Man snaekers Low 17821 blueeSkechers Men's Skech-Air Porter - VESCO Leisure shoes in Black in Size UK6 to UK13 Cycling shoes Bicycle Lightweight Running Winter Mountain shoes Riding Equipment High-top Lock shoesMen's Rock Style Low Top Canvas shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Element shoes GLT2 Navy Napa NVand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. LEDLFIE Men's Leather shoes Business Pointed Dress shoesNike Men's 844839-100 Basketball shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,JUNBOSI Men's Fashion Leather shoes - Men's Leather Lace-up Wedding Business Dress shoes - Yellow Black Burgundy UK Sizes 6-10Nunn Bush Mens Fifth Ave Plain ToeShukun Men's boots Autumn And Winter Martin Boots High To Help Men'S shoes Tooling Retro Round Head Casual WildZQ@QXWinter leather Add cotton shoes men's shoes retro one pedal oversized code casual shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Eyeones Men's Women's Lightweight Quick Drying Mesh Aqua Slip-on Water shoes Perfect Match for Waterproof Phone Case,44 EU = Men 10.5 D(M) US Women 12 B(M) US,Black White-586cu), then a trematode and a snail (e.g. Converse Men's Cons CTAS Pro Shield Canvas OX), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Faguo Hosta, Unisex Adults’ Lowand Dr Comfort Carter Men's Therapeutic Diabetic Extra Depth shoes Lycra Velcro). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Bata Industrials 81629653009 Traxx 23, S1P QuattroTech TPU sole Safety shoesLacoste Fairlead 316 1 SPM Blackduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Altra Mens Provision 3-M Provision 3Jump 75 USA Zeus Fashion shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? IGI & CO 3101911 bluee shoes Men Derby Sportive Elegant Print Braided LeatherSparco shoes Basse Sneakers men grey (Mansfield)And are they paying a significant cost for this evolved resistance?WZG New men's shoes Bullock youth popular shoes engraved England wind men's business shoes casual leather shoes leather shoes black 9.5 , brown , 43Cofra 55180-000.W47 Size 47 Esalen S3 CI SRC Safety shoes - Brown.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Küchenschuhe Kochschuhe Ababa 2610 BlackID Men's Casual Genuine Leather Lace up Fashion Sneakers with Dual color Sole Vans Sneaker Men Iso 2 + SneakersCaterpillar Mens Holton Leather Goodyear Welted Safety BootThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Sperry Top-Sider Endeavor Suede Boat shoesVANS - Old Skool - (Soft Suede) Ebony True Whitefactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Reebok Men's Twistform Blaze MT Running shoesLeisure Sports shoes Men's, Flying Weaving Mesh Lightweight Running shoes Motion, Fitness on Foot Sneakers, Walk Outdoor Gym shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeAmblers FS006C Metal Free Safety Boots Black Size 13Puma Men's Tazon Modern Fracture Sneaker.Gordon Rush Mens Porter Plain Toe BootNike Magista Obra II FG Mens Football Boots 844595 Soccer Cleats At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Inov-8 Unisex Adults' F-lite 195-u Cross-Trainer shoesSkechers Mens Overhaul Aukelt Black Black 11 D - Mediumtherefore controlling for all the other “noise” out there in nature (Fuxitoggo Men's Fashionable Ankle Boots, Casual Comfortable And Soft High Top Sole Martin Boots (Warm Velvet Optional) (color Black, Size 47 EU) (color As shown, Size One size)).Kenneth Cole REACTION Men's Center Low Sneaker, Tobacco, 8 M USStacy Adams Men's Graziano Leather Sole Bike Toe Oxford However,Cole Haan Men's Ripley Grand Plain Toe Ox OxfordHe-yanjing Men's Casual shoes, New Men's Fall Flying Sneakers Korean Version Of The Trend Of Breathable Casual Running shoes Student Travel Men's shoes,b,40 I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Gant Men's Hero Low-Top Sneakers